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Nucleoplasmin11/15/2023 ![]() ![]() HIV-1 Rev has a nucleolar distribution which is similar to B23.1, but with different trafficking rates The interaction of Rev with NPM1 is decreased by RRE HIV-1 Rev interacting protein, nucleophosmin 1 (NPM1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. Tandem affinity purification and mass spectrometry analysis identify nucleophosmin (NPM1 nucleolar phosphoprotein B23), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells Expression Ubiquitous expression in ovary (RPKM 256.2), lymph node (RPKM 146.3) and 25 other tissues See more Orthologs mouse all NEW Try the new Gene table Dozens of pseudogenes of this gene have been identified. Mutations in this gene are associated with acute myeloid leukemia. This protein is also known to sequester the tumor suppressor ARF in the nucleolus, protecting it from degradation until it is needed. The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the nucleus to the cytoplasm. Full Name nucleophosmin 1 provided by HGNC Primary source HGNC:HGNC:7910 See related Ensembl:ENSG00000181163 MIM:164040 AllianceGenome:HGNC:7910 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo Also known as B23 NPM Summary The protein encoded by this gene is involved in several cellular processes, including centrosome duplication, protein chaperoning, and cell proliferation. ![]()
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